Matrix-Driven Delivery (MDD) 給藥系統

本給藥系統由一個可生物吸收的基質組成，含有定量可控的活性給藥成分，可以以設定的劑量在一定時間范圍內進行給藥。

給藥天數及劑量的選擇：依據研究人員實驗需要確定，如某實驗需要在3周內給大鼠皮下給某種藥x mg，首先在本公司產品目錄中選取該種藥物，然后選取21天緩釋時間，劑量選擇可以如下方式進行：21天共給藥量或每天給藥量，計算出總的藥物劑量。本公司常規的給藥時間有21，,60，90天，即可選擇21天的給藥時間（如常規給藥時間不滿足實驗設計，可公司進行產品定制）。同樣，給如本公司提供的常規給藥劑量不滿足實驗設計，也可公司進行產品定制。本公司可根據客戶需要在給藥系統中加入可在規定期間釋放一定劑量的活性藥物。

給藥方法：皮下（一般選取背部或頸部皮膚松弛部位）植入本給藥系統。手工植入方法為選取植入部位，切開一個藥丸直徑相當的切口，以無菌鑷子自切口探入，深入皮下至2cm處，用鑷子將藥丸送入離切口2cm處，縫合切口即可。切忌：（1）切口及鑷子探入時傷及肌肉層，可引起炎癥，影響藥物釋放及實驗；（2）鑷子送入藥丸時切勿破壞藥丸，否則影響藥丸緩釋效應，影響實驗結果。

使用套針給藥（另售）：將藥丸放入給藥套針，選取給藥點，扎入針頭，在不傷及肌肉的情況下將針深入扎入處2cm，將藥丸推入皮下，抽出套針即可，無需縫合。

相關參考文獻：

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